Motif ID: FOX{D1,D2}.p2

Z-value: 2.312


Transcription factors associated with FOX{D1,D2}.p2:

Gene SymbolEntrez IDGene Name
FOXD1 2297 forkhead box D1
FOXD2 2306 forkhead box D2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FOXD1chr5_-_727795850.693.3e-03Click!
FOXD2chr1_+_47674275-0.591.6e-02Click!


Activity profile for motif FOX{D1,D2}.p2.

activity profile for motif FOX{D1,D2}.p2


Sorted Z-values histogram for motif FOX{D1,D2}.p2

Sorted Z-values for motif FOX{D1,D2}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOX{D1,D2}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_+_85069217 6.026


chr2_-_189752575 4.699 NM_000393
COL5A2
collagen, type V, alpha 2
chr1_-_177378801 4.480 NM_001136000
NM_001168239
NM_005158
ABL2


v-abl Abelson murine leukemia viral oncogene homolog 2


chr12_+_13240868 4.447 NM_001423
EMP1
epithelial membrane protein 1
chr8_-_29263714 4.366 NM_001394
DUSP4
dual specificity phosphatase 4
chr6_+_74462577 4.266 CD109
CD109 molecule
chr12_+_13240983 4.249 EMP1
epithelial membrane protein 1
chr12_+_13240987 4.241 EMP1
epithelial membrane protein 1
chr3_-_71196696 4.238 FOXP1
forkhead box P1
chr7_+_1543644 4.222 MAFK
v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
chr7_+_134114957 3.919 CALD1
caldesmon 1
chr16_+_54070302 3.788 NM_004530
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr7_+_134114912 3.786 CALD1
caldesmon 1
chr7_+_134114701 3.688 NM_004342
NM_033138
NM_033157
CALD1


caldesmon 1


chr4_+_120167264 3.632 SYNPO2
synaptopodin 2
chr6_+_74462226 3.620 NM_001159587
NM_001159588
NM_133493
CD109


CD109 molecule


chr6_+_74462485 3.534 CD109
CD109 molecule
chr10_+_47875229 3.469 NM_001040084
NM_001098845
ANXA8L2
ANXA8
ANXA8L1
annexin A8-like 2
annexin A8
annexin A8-like 1
chr10_+_104525877 3.462 NM_017787
C10orf26
chromosome 10 open reading frame 26
chr6_+_74462630 3.462 CD109
CD109 molecule
chr2_-_101457596 3.458 NM_001145664
RFX8
regulatory factor X, 8
chr4_-_141294682 3.444 NM_018717
MAML3
mastermind-like 3 (Drosophila)
chr6_+_74462654 3.426 CD109
CD109 molecule
chr19_+_46417099 3.369 AXL
AXL receptor tyrosine kinase
chr19_+_46417117 3.286 AXL
AXL receptor tyrosine kinase
chr2_-_162808123 3.216 NM_004460
FAP
fibroblast activation protein, alpha
chr1_-_20682541 3.215


chr4_+_14985272 3.171 NM_001135171
C1QTNF7
C1q and tumor necrosis factor related protein 7
chr19_+_46416971 3.081 AXL
AXL receptor tyrosine kinase
chr3_+_64645819 3.074 LOC100507098
hypothetical LOC100507098
chr19_+_46416938 3.070 NM_001699
NM_021913
AXL

AXL receptor tyrosine kinase

chr19_+_46416975 3.028 AXL
AXL receptor tyrosine kinase
chr12_+_12935222 2.960 NM_003979
GPRC5A
G protein-coupled receptor, family C, group 5, member A
chr8_-_119192985 2.893 NM_000127
EXT1
exostosin 1
chr11_+_101488380 2.823 NM_001195045
YAP1
Yes-associated protein 1
chr8_-_127639647 2.796 FAM84B
family with sequence similarity 84, member B
chr19_-_63301402 2.782 ZSCAN18
zinc finger and SCAN domain containing 18
chr9_+_117955890 2.749 NM_002581
PAPPA
pregnancy-associated plasma protein A, pappalysin 1
chr10_+_24795465 2.748 KIAA1217
KIAA1217
chr10_+_24795446 2.741 KIAA1217
KIAA1217
chr19_-_63301418 2.700 NM_001145543
NM_001145544
NM_023926
ZSCAN18


zinc finger and SCAN domain containing 18


chr21_+_29439768 2.672 C21orf7
chromosome 21 open reading frame 7
chr7_-_27102049 2.669 NM_005522
NM_153620
HOXA1

homeobox A1

chr11_-_114880275 2.626 NM_001098517
NM_014333
CADM1

cell adhesion molecule 1

chr19_-_63301386 2.619 ZSCAN18
zinc finger and SCAN domain containing 18
chr6_-_30151526 2.600 NM_170769
NM_025236
RNF39

ring finger protein 39

chr6_-_105734535 2.593 NM_022361
POPDC3
popeye domain containing 3
chr8_-_134378630 2.572 NM_001135242
NM_006096
NDRG1

N-myc downstream regulated 1

chr17_-_8000362 2.552 PER1
period homolog 1 (Drosophila)
chr4_-_152368492 2.531 SH3D19
SH3 domain containing 19
chr15_-_68781662 2.434 NM_001008224
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr3_-_126088530 2.393 ITGB5
integrin, beta 5
chr12_+_95112385 2.378 ELK3
ELK3, ETS-domain protein (SRF accessory protein 2)
chr10_+_63478974 2.356 ARID5B
AT rich interactive domain 5B (MRF1-like)
chr11_+_834445 2.354 NM_001025237
TSPAN4
tetraspanin 4
chr11_-_62070775 2.336 AHNAK
AHNAK nucleoprotein
chr18_-_21184824 2.292


chr6_+_12398514 2.227 NM_001168319
NM_001955
EDN1

endothelin 1

chr12_-_28014151 2.206 NM_198964
NM_198966
PTHLH

parathyroid hormone-like hormone

chr18_+_54681040 2.203 NM_018181
ZNF532
zinc finger protein 532
chr5_-_142045770 2.184 NM_000800
FGF1
fibroblast growth factor 1 (acidic)
chr1_+_24518501 2.177 NM_001195010
GRHL3
grainyhead-like 3 (Drosophila)
chrX_-_106846684 2.083 TSC22D3
TSC22 domain family, member 3
chr7_+_28692122 2.046 NM_001011666
CREB5
cAMP responsive element binding protein 5
chr15_+_97009194 2.008 IGF1R
insulin-like growth factor 1 receptor
chr22_+_36928972 1.975 NM_001161573
MAFF
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chr21_-_34820916 1.963 NM_203418
RCAN1
regulator of calcineurin 1
chr12_-_29827952 1.948 NM_001193451
TMTC1
transmembrane and tetratricopeptide repeat containing 1
chr7_-_5429702 1.936 NM_001080495
TNRC18
trinucleotide repeat containing 18
chr1_+_24518398 1.926 NM_198173
NM_198174
GRHL3

grainyhead-like 3 (Drosophila)

chr8_+_70567581 1.910 NM_001128205
NM_001128206
SULF1

sulfatase 1

chr12_+_95112131 1.909 NM_005230
ELK3
ELK3, ETS-domain protein (SRF accessory protein 2)
chr7_+_28415495 1.891 LOC401317
hypothetical LOC401317
chr1_-_20685314 1.891 NM_018584
CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr7_-_139987044 1.886 DENND2A
DENN/MADD domain containing 2A
chr5_-_142046175 1.885 NM_033136
FGF1
fibroblast growth factor 1 (acidic)
chr16_-_85099941 1.861 LOC400550
hypothetical LOC400550
chr12_+_32578513 1.859 FGD4
FYVE, RhoGEF and PH domain containing 4
chr4_-_186693574 1.839 NM_001114107
NM_014476
PDLIM3

PDZ and LIM domain 3

chr13_-_35818396 1.836 SPG20
spastic paraplegia 20 (Troyer syndrome)
chr5_+_36644187 1.808 NM_001166695
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr11_+_834062 1.806 NM_001025234
TSPAN4
tetraspanin 4
chr10_-_92671005 1.802 NM_014391
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr2_-_192419896 1.801 SDPR
serum deprivation response
chr11_+_834111 1.799 TSPAN4
tetraspanin 4
chr8_+_70567634 1.775 SULF1
sulfatase 1
chr1_-_199732323 1.775 NM_001193572
CSRP1
cysteine and glycine-rich protein 1
chr3_-_170348215 1.771 NM_001164000
MECOM
MDS1 and EVI1 complex locus
chr8_+_77756077 1.755 ZFHX4
zinc finger homeobox 4
chr12_+_105220638 1.753 NM_152772
TCP11L2
t-complex 11 (mouse)-like 2
chr13_-_35818491 1.746 SPG20
spastic paraplegia 20 (Troyer syndrome)
chr13_-_37341859 1.734 NM_001135955
NM_001135956
NM_001135957
NM_001135958
NM_003306
NM_016179
TRPC4





transient receptor potential cation channel, subfamily C, member 4





chr18_+_64616296 1.731 NM_024781
CCDC102B
coiled-coil domain containing 102B
chr10_-_105411339 1.729 SH3PXD2A
SH3 and PX domains 2A
chrX_-_106846924 1.724 NM_004089
TSC22D3
TSC22 domain family, member 3
chr3_-_71262405 1.719 FOXP1
forkhead box P1
chr8_-_127639892 1.717 NM_174911
FAM84B
family with sequence similarity 84, member B
chr1_-_24342158 1.711 NM_021258
IL22RA1
interleukin 22 receptor, alpha 1
chr17_-_23686566 1.709 NM_174887
IFT20
intraflagellar transport 20 homolog (Chlamydomonas)
chr8_+_77756061 1.691 NM_024721
ZFHX4
zinc finger homeobox 4
chr7_-_27180398 1.685 NM_018951
HOXA10
homeobox A10
chr1_+_207668787 1.675 NM_001104548
LOC642587
NPC-A-5
chr11_-_85074848 1.674 NM_152723
CCDC89
coiled-coil domain containing 89
chr3_-_115825742 1.664 NM_001164347
ZBTB20
zinc finger and BTB domain containing 20
chr11_-_56846246 1.655 TNKS1BP1
tankyrase 1 binding protein 1, 182kDa
chr9_-_134809774 1.645 TSC1
tuberous sclerosis 1
chr7_+_106596641 1.636 NM_012257
HBP1
HMG-box transcription factor 1
chr3_-_71262426 1.630 FOXP1
forkhead box P1
chr16_+_68516401 1.619 NM_199424
WWP2
WW domain containing E3 ubiquitin protein ligase 2
chr17_+_23686674 1.616 NM_021137
TNFAIP1
tumor necrosis factor, alpha-induced protein 1 (endothelial)
chr1_-_207892296 1.612 NM_001127641
LAMB3
laminin, beta 3
chr10_+_102782156 1.603 SFXN3
sideroflexin 3
chr4_-_165523856 1.603 NM_001166373
MARCH1
membrane-associated ring finger (C3HC4) 1
chr12_-_74711642 1.591 NM_007350
PHLDA1
pleckstrin homology-like domain, family A, member 1
chr10_-_92670764 1.588 ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr20_-_49612745 1.583 NFATC2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
chr4_-_99283323 1.581 NM_174952
C4orf37
chromosome 4 open reading frame 37
chr19_+_13767207 1.574 NM_023072
ZSWIM4
zinc finger, SWIM-type containing 4
chr9_-_72218098 1.567 KLF9
Kruppel-like factor 9
chr16_+_27248806 1.543 IL4R
interleukin 4 receptor
chr9_+_5500544 1.507 NM_025239
PDCD1LG2
programmed cell death 1 ligand 2
chr7_-_27149750 1.484 NM_019102
HOXA5
homeobox A5
chr12_-_106011437 1.434 CRY1
cryptochrome 1 (photolyase-like)
chr18_+_30544193 1.419 NM_001198941
NM_032978
DTNA

dystrobrevin, alpha

chr22_-_30018329 1.408 NM_001135911
NM_052880
PIK3IP1

phosphoinositide-3-kinase interacting protein 1

chrX_-_19598912 1.400 NM_001184960
SH3KBP1
SH3-domain kinase binding protein 1
chr2_-_192420168 1.397 NM_004657
SDPR
serum deprivation response
chr2_+_188865634 1.384 NM_016315
GULP1
GULP, engulfment adaptor PTB domain containing 1
chr3_+_42107711 1.368 NM_001042646
TRAK1
trafficking protein, kinesin binding 1
chr9_-_134809816 1.362 NM_000368
NM_001162426
NM_001162427
TSC1


tuberous sclerosis 1


chr15_-_58671929 1.362 NM_134262
RORA
RAR-related orphan receptor A
chr10_+_102782151 1.354 SFXN3
sideroflexin 3
chr5_-_58607673 1.346 NM_001197220
PDE4D
phosphodiesterase 4D, cAMP-specific
chr2_+_188865796 1.338 GULP1
GULP, engulfment adaptor PTB domain containing 1
chr1_+_183970093 1.334 NM_031935
HMCN1
hemicentin 1
chr20_-_49612574 1.320 NM_001136021
NFATC2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
chr10_+_47216925 1.319 NM_001630
ANXA8L2
ANXA8
annexin A8-like 2
annexin A8
chr5_-_16561936 1.299 NM_019000
FAM134B
family with sequence similarity 134, member B
chr10_-_46593923 1.278 NM_001040084
NM_001098845
ANXA8L2
LOC653110
ANXA8
ANXA8L1
annexin A8-like 2
hypothetical LOC653110
annexin A8
annexin A8-like 1
chr18_-_12646730 1.277 NM_001128627
SPIRE1
spire homolog 1 (Drosophila)
chr2_-_68400516 1.253 NM_001111101
NM_015463
CNRIP1

cannabinoid receptor interacting protein 1

chr2_+_101680594 1.247 NM_004834
NM_145686
NM_145687
MAP4K4


mitogen-activated protein kinase kinase kinase kinase 4


chr10_-_44794146 1.241 NM_007021
C10orf10
chromosome 10 open reading frame 10
chr3_-_55489973 1.238 WNT5A
wingless-type MMTV integration site family, member 5A
chr5_+_72287630 1.234 FCHO2
FCH domain only 2
chr5_+_72287625 1.223


chr7_+_113513828 1.215 FOXP2
forkhead box P2
chr6_+_134800533 1.210 LOC154092
hypothetical LOC154092
chr22_-_30016707 1.206 PIK3IP1
phosphoinositide-3-kinase interacting protein 1
chr10_+_99390459 1.205 PI4K2A
phosphatidylinositol 4-kinase type 2 alpha
chr12_+_123339662 1.204 NM_181709
FAM101A
family with sequence similarity 101, member A
chr12_-_106011715 1.198 NM_004075
CRY1
cryptochrome 1 (photolyase-like)
chr16_-_28457728 1.196 NUPR1
nuclear protein, transcriptional regulator, 1
chr17_+_56109940 1.195 NM_001099432
NM_017679
BCAS3

breast carcinoma amplified sequence 3

chr6_+_76515690 1.146 MYO6
myosin VI
chr17_-_60088459 1.137 SMURF2
SMAD specific E3 ubiquitin protein ligase 2
chr1_+_13784553 1.130 NM_001006624
NM_001006625
PDPN

podoplanin

chr9_-_3515973 1.113 NM_002919
NM_134428
RFX3

regulatory factor X, 3 (influences HLA class II expression)

chr6_+_149109841 1.108 NM_005715
UST
uronyl-2-sulfotransferase
chr7_-_95063738 1.105 NM_002612
PDK4
pyruvate dehydrogenase kinase, isozyme 4
chr12_+_52696908 1.100 NM_014620
NM_153693
HOXC4
HOXC6
homeobox C4
homeobox C6
chr17_+_3326045 1.099 NM_000049
ASPA
aspartoacylase
chr3_-_143350898 1.098 NM_001178138
NM_001178139
TFDP2

transcription factor Dp-2 (E2F dimerization partner 2)

chr7_+_30140868 1.094 NM_152793
C7orf41
chromosome 7 open reading frame 41
chr8_-_133841988 1.088 NM_001145153
NM_144649
TMEM71

transmembrane protein 71

chr16_+_85169615 1.087 NM_005250
FOXL1
forkhead box L1
chr14_+_22136968 1.087 NM_022060
ABHD4
abhydrolase domain containing 4
chr2_+_109909139 1.086 NM_001164463
NM_005054
RGPD8
RGPD5
RANBP2-like and GRIP domain containing 8
RANBP2-like and GRIP domain containing 5
chr4_+_124537334 1.073 NM_199327
SPRY1
sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr10_+_99390431 1.056 NM_018425
PI4K2A
phosphatidylinositol 4-kinase type 2 alpha
chr11_+_20005704 1.054 NAV2
neuron navigator 2
chr7_+_134226690 1.049 NM_033139
NM_033140
CALD1

caldesmon 1

chr5_+_72287509 1.044 NM_001146032
NM_138782
FCHO2

FCH domain only 2

chr4_+_86615275 1.043 NM_001025616
ARHGAP24
Rho GTPase activating protein 24
chr10_+_123912930 1.042 TACC2
transforming, acidic coiled-coil containing protein 2
chr2_+_12774264 1.041 NM_021643
TRIB2
tribbles homolog 2 (Drosophila)
chr12_+_48421559 1.022 NM_003217
TMBIM6
transmembrane BAX inhibitor motif containing 6
chr6_-_56615544 1.022 NM_001723
NM_015548
DST

dystonin

chr22_+_36928011 1.011 MAFF
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chr17_-_37196463 1.010 NM_002230
NM_021991
JUP

junction plakoglobin

chr3_+_189413414 1.007 NM_005578
LPP
LIM domain containing preferred translocation partner in lipoma
chr9_-_3515721 1.003 RFX3
regulatory factor X, 3 (influences HLA class II expression)
chr12_+_48421617 1.003 TMBIM6
transmembrane BAX inhibitor motif containing 6
chr5_-_142763481 0.999 NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr1_-_115060904 0.996 NRAS
neuroblastoma RAS viral (v-ras) oncogene homolog
chr9_+_112470871 0.986 NM_001166280
NM_001166281
NM_005592
MUSK


muscle, skeletal, receptor tyrosine kinase


chr4_+_120167770 0.965 SYNPO2
synaptopodin 2
chr20_-_42584006 0.960 SERINC3
serine incorporator 3
chr1_-_115060857 0.958 NRAS
neuroblastoma RAS viral (v-ras) oncogene homolog
chr1_-_166373434 0.953 GPR161
G protein-coupled receptor 161
chr10_+_23768203 0.951 NM_001145373
OTUD1
OTU domain containing 1
chr10_+_123913094 0.946 NM_006997
NM_206860
TACC2

transforming, acidic coiled-coil containing protein 2

chr3_-_64186151 0.943 NM_198859
PRICKLE2
prickle homolog 2 (Drosophila)
chr5_-_142763418 0.940 NM_000176
NM_001020825
NM_001024094
NR3C1


nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)


chr1_-_60164912 0.938 NM_000775
CYP2J2
cytochrome P450, family 2, subfamily J, polypeptide 2
chr1_-_85816520 0.934 NM_001134445
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr1_+_149437602 0.932 NM_001135636
NM_001135637
NM_001135638
NM_003557
PIP5K1A



phosphatidylinositol-4-phosphate 5-kinase, type I, alpha



chr6_+_139136349 0.927 NM_015439
CCDC28A
coiled-coil domain containing 28A
chr17_+_9686572 0.918 GLP2R
glucagon-like peptide 2 receptor
chr5_-_150440792 0.917 TNIP1
TNFAIP3 interacting protein 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.83 4.55e-03 GO:0009790 embryo development
3.72 1.94e-02 GO:2000027 regulation of organ morphogenesis
2.12 2.43e-02 GO:0007389 pattern specification process
1.48 3.09e-02 GO:0009653 anatomical structure morphogenesis
2.16 3.41e-02 GO:0022603 regulation of anatomical structure morphogenesis

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.56 1.71e-02 GO:0001071 nucleic acid binding transcription factor activity
1.56 1.71e-02 GO:0003700 sequence-specific DNA binding transcription factor activity
1.66 3.78e-02 GO:0043565 sequence-specific DNA binding